Badrilla，Badrilla代理，Badrilla北京代理，Badrilla國內代理，Badrilla總代理，Badrilla一級代理，Badrilla中國代理

badrilla 生物技術公司成立于2003年，總部位于利英國。badrilla使分配特殊的單克隆抗體和多克隆抗體的蛋白質和磷酸化蛋白的目標心血管。 badrilla生命科學試劑公司專注于研究工具為心血管疾病的研究，尤其是對心肌興奮收縮偶聯(lián)。badrilla為工業(yè)界和學術界的研究實驗室制造 和驗證抗體的心臟蛋白和磷酸蛋白。

上海起發(fā)實驗試劑有限公司badrilla專業(yè)代理，具體產(chǎn)品信息歡迎電詢：

anti-Phospholamban Phospho Threonine-17 anti-serum (A010-13)

Description: A fully validated, highly specific rabbit polyclonal anti-sera to Threonine-17 phosphorylated forms of Phospholamban (anti-PLB PT-17)

Background: Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca²⁺/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure.

Unit Volume: 20 ul

Tested Applications: Western Blot (1:5000 dilution), IHC Microscopy (1:200 dilution)

Antibody form: Lyophilised anti-serum

Species recognition: All mammalian species, when phosphorylated on Thr-17

Full Publication list: 111 papers

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